Crimson Publishers-Disabilities

Re-Visiting the Role of Intra-Partum Cardio-Tocography (I-P CTG) In Cerebral Palsy Jurisprudence: Time to Take Cognizance by George Gregory Buttigieg KM* in Degenerative Intellectual & Developmental Disabilities Both clinical obstetrics as well the relevant medico-legal litigation were severely led down by false scientific conclusions emanating from the USA in the 1960's. The false assumptions considered birth asphyxia as the predominant cause of newborn Cerebral Palsy and proclaimed the just introduced fetal cardio-tocography (CTG), as the great saviour from CP through the detection of intra-partum hypoxia. Although today, fifity odd years later, science that neither conclusion is correct, CTG has retained its misplaced strength in CP litigation. Not only does it still hold much pre-eminence in both UK and US jurisprudence, but sometimes, it constitutes the sole basis of discussion. https://www.crimsonpublishers.com/didd/fulltext/DIDD.000507.php  ...

Homocysteine Serum Levels and Methylenetetrahydrofolate (MTHFR) C677T Genotype in Patients with Parkinson's Disease, with and without Levodopa Therapy by Eleonora DŽoljić* and Vladimir Kostić  in Degenerative Intellectual & Developmental Disabilities Both methylenetetrahydrofolate (MTHFR) C677T genotype and levodopa treatment may give rise to elevated serum homocysteine levels in parkinsonian patients. We aimed to clarify the interplay of these factors in pathogenesis of Parkinson's disease (PD)-related hyperhomocysteinemia . Total serum levels of homocysteine (tHcy) and MTHFR C677T genotype were investigated in levodopa -treated and -untreated parkinsonian ("de novo”) patients, as well as in control healthy subjects matched by age and gender (N=83, 30 and 53, respectively). MTHFR C677T genotypes were equally distributed in PD patients and control subjects, the T allele homozygosity being observed in app. 12-17% cases. https://crimsonpublishe...

Anti-Cancer Effects of Zinc (II) Ion in Tumor Formation and Growth, Proliferation, Metastasis and DNA Damage by Ishida T* in Degenerative Intellectual & Developmental Disabilities From the results on antibacterial activities, the killing mechanisms have become clear that bacteriolysis for S. aureus peptidoglycan(PGN) cell wall is due to the inhibition of PGN elongation by the activities of PGN autolysins of amidases, and the other, for E. coli cell wall are due to destruction of outer membrane structure by degrading of lipoprotein at C-, N-terminals, owing to PGN formation inhibition by activities of PGN autolysins of amidase and carboxypeptidase-transpeptidase.  https://crimsonpublishers.com/didd/fulltext/DIDD.000505.php  For more open access journals in Crimson Publishers please click on link: https://crimsonpublishers.com/ For more articles in open access Disabilities journals please click on link: https://crimsonpublishers.com/didd/...

Case History of a Novel Treatment Approach for Congenital Cardiomyopathy due to Carnitine Transporter Deficiency by Arun Mukherjee*, Vinod Sharma, Indrajit Neil Roy and Meena Gupta in Degenerative Intellectual & Developmental Disabilities       This is a case study of a novel experimental therapy approach in a rare treatment non-responsive potentially fatal Carnitine Transporter Deficiency Congenital Cardiomyopathy. The child's LVEF was down to about 24% at presentation. As a last resort, we tried out a new multidisciplinary therapy approach. It restored his treatment response and raised his LVEF to a persistent level of 80 to 84% as followed up for last two years. Three of his similarly affected siblings: two brothers and one sister, had earlier succumbed in spite of optimum Levo-Carnitine supplement (the only approved treatment) as provided by one of the most prestigious Medical Institutes of his country https://crimsonpublishers....

Intellectual Disability, Childhood Overweight and Obesity by Ray Marks* in Degenerative Intellectual & Developmental Disabilities Exercise, a vital health-promoting activity, regardless of health status, is often recommended for helping to prevent or reduce the onset and progression of obesity, a major global health concern. Yet, even though youth with disabilities may be at a high risk for obesity, little effort seems to be applied towards encouraging the use exercise among youth with intellectual or developmental disabilities. This brief attempts to explain why obesity prevention is needed and how to promote this among this special needs group of youth, where participating in physical activity and sustaining this is very challenging.   https://crimsonpublishers.com/didd/fulltext/DIDD.000503.php  

Social Isolation in the Elderly; Physical Activity to the Rescue by Ogundiran Opeyemi Olufemi* in  Degenerative Intellectual & Developmental Disabilities Human beings are naturally sociable, and this evidence can be seen in the establishment of many types of relationships among them. There are endless benefits associated with social interactions which are critical to the maintenance of optimal health. A socially-isolated individual usually lacks a sense of belonging among his or her peers which could inevitably lead to depression or its associated symptoms especially in the geriatric population. The problem of social isolation among older adults is emerging due to several risk factors. The major aim of this opinion article is to critically examine the relevance of physical activity in tackling social isolation among the elderly. https://crimsonpublishers.com/didd/fulltext/DIDD.000502.php

The Stupidity of Perception by James F Welles* in Degenerative Intellectual & Developmental Disabilities In vertebrates, incoming sensory data are picked up by the five major senses: sight, hearing, taste, smell and touch. However, even in monkeys, info picked up by the eyes does not go directly from the optic nerve to the visual cortex of the brain; it first passes through temporal lobe where it is edited and modified [1]. In the case of our own species, this process can lead to maladaptation through limited, distorted and/or inventive tinkering with data. It is a feature common to schematic systems and makes stupidity a normal part of the human experience, since stupidity is based on the subjective nature of perception, which requires the observer to be actively involved in the process [2].  https://crimsonpublishers.com/didd/fulltext/DIDD.000501.php